Growth Factor Injections (GFc)

WHAT IS GFC THERAPY?

                      GFC is an innovative Concentrate Therapy for treatment of Hair Loss, which is proven hair loss treatment that can regenerate and promote hair growth for men and women by using your own plasma and growth factors to target areas of hair loss and it also trigger the growth phase in the hormonally challenged hair roots. It is equally effective in both male & females. 

Pure GFC is obtained from Autologous (patient’s) blood which is completely acellular obtained by activating platelets. A Platelet activating solution is used to activate platelets and to release various GFs from α Granules prior to centrifugation (in vitro) this ensures no platelet loss + all platelets release GFs from α Granules. GFc is minimum Operator dependent variation, which is usually seen with PRP.

During the procedure clinicians takes 20ml of blood from the patient and distributed in 4 GFc Tubes equally and allow to stand for 30 minutes after gently mixed for 6-7 times. This activates almost all platelets by platelet activating solution present in tubes. After the activation the tubes are centrifuged for 10 mins in 3400 RPM which will separate the red blood cell and the plasma which has activated growth factors, which will be injected in the targeted area. Overall procedure will take approximately one hour.

Advantages of Gfc

·        Standardization in Gfc preparing protocol.

·        Doesn’t require multiple follow up sessions after 3 sessions. 

·        very low Operator dependent variation in final output and platelet concentration

·        consistent platelet Output

·        Though platelets are collected in high concentration, there won’t be loss of variable amounts of platelets during the procedure

GF’s and their functions

TGF-α

Tumor growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family. TGF-α function is mediated through binding the EGF receptor (EGFR) to activate receptor tyrosine kinase signalling. TGF-α functions as a mitogen to activate epithelial cell proliferation, growth, and differentiation.

 IGF-1

Insulin-like growth factor-1, arguably the most studied, has an essential role in hair cycle control as well as hair shaft differentiation during the development of hair follicles 1. IGF-1 has been reported to promote hair follicle growth in vitro by regulating cellular proliferation .Also, IGF-1 can induce 5α-reductase in human skin fibroblasts, leading to an increased conversion of testosterone to DHT

PDGF

Platelet-derived growth factor (PDGF) is a potent activator for cells of mesenchymal origin. PDGF stimulates chemotaxis, proliferation, and new gene expression in monocytes-macrophages and fibroblasts in vitro, cell types considered essential for tissue repair.

FBGF

A fibroblast is the most common type of cell found in connective tissue. Fibroblasts secrete collagen proteins that are used to maintain a structural framework for many tissues. They also play an important role in healing wounds.

EGF

Epidermal growth factor is a protein which is made by many cells in the body that stimulates cell growth and differentiation by binding to its receptor, EGFR

VEGF

VEGF is a key mediator of angiogenesis(formation of new blood vessels) as it facilitates blood vessel growth and remodelling processes, as well as providing mitogenic and survival stimuli for endothelial cells. VEGF also influences the immune system in a number of different ways.

FGFB

FGF2, also known as basic fibroblast growth factor and FGF-β, is a growth factor and signalling protein encoded by the FGF2 gene. It binds to and exerts effects via specific fibroblast growth factor receptor proteins, themselves a family of closely related molecules.